FFL Helper / St Louis / Knoxville

STL → TYS

St Louis to Knoxville

Compare one-way fares for flights from St Louis to Knoxville.

Lowest fare $269

Distance 391 mi

Flight time 5h 25m

Airports STL–TYS

Search this route

Ad. Ticket links are affiliate ads. We may earn a commission if you book. Advertising disclosure

By month: August 2026 from $269

Price calendar

August 2026

From $269

Mon

Tue

Wed

Thu

Fri

Sat

Sun

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29 $269

30

31

September 2026

Mon

Tue

Wed

Thu

Fri

Sat

Sun

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

Upcoming dates

Knoxville TYS

$269

Aug 29, 6:50am · 5h 25m · 1 stop

STL → TYS · Southwest Airlines

Tickets

About this route

This calendar shows dated one-way fares from St Louis to Knoxville. Use it to see which days are cheaper before you search tickets.

Flight time and airport codes on this page are for the sample itinerary we have on file. Always confirm the live routing when you book St Louis to Knoxville.